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PDF:Observation management of pulmonary embolism and agreement with claims-based and clinical risk stratification criteria in United States patients: a retrospective analysis, Nguyen E, et al.

Guidelines suggest observation stays are appropriate for pulmonary embolism (PE) patients at low risk for early mortality. The investigators sought to asses agreement between United States (US) observation management of PE and claims-based clinical risk stratification criteria.

Link:Thrombosis: a major contributor to global disease burden, Raskob GE, et al.

Thrombosis is the common pathology underlying ischemic heart disease, ischemic stroke, and venous thromboembolism (VTE). The Global Burden of Disease Study 2010 (GBD 2010) documented that ischemic heart disease and stroke collectively caused 1 in 4 deaths worldwide. GBD 2010 did not report data for VTE as a cause of death and disability.

Link:Incidence of Chronic Thromboembolic Pulmonary Hypertension after Pulmonary Embolism, Pengo V, et al.

Chronic thromboembolic pulmonary hypertension (CTPH) is associated with considerable morbidity and mortality. Its incidence after pulmonary embolism and associated risk factors are not well documented.

Link:Epidemiology, Pathophysiology, Stratification, and Natural History of Pulmonary Embolism, Giordano NJ, et al.

Pulmonary embolism (PE) is a common and potentially fatal form of venous thromboembolism (VTE) that can be challenging to diagnose and manage. PE occurs when there is obstruction of the pulmonary vasculature and is a common cause of morbidity and mortality in the United States.

Link:30-Year Mortality After Venous Thromboembolism, Søgaard KK, et al.

Studies on long-term mortality after venous thromboembolism (VTE) are sparse. Using Danish medical databases, a 30-year nationwide population-based cohort study was conducted of 128,223 patients with first-time VTE (1980–2011) and a comparison cohort of 640,760 people from the general population (without VTE) randomly matched by sex, year of birth, and calendar period.

Link:The Epidemiology of Venous Thromboembolism, White RH.

Approximately one third of patients with symptomatic VTE manifest pulmonary embolism (PE), whereas two thirds manifest deep vein thrombosis (DVT) alone.


Link:Simplification of the pulmonary embolism severity index for prognostication in patients with acute symptomatic pulmonary embolism, Jiménez D, et al.

The Pulmonary Embolism Severity Index (PESI) estimates the risk of 30-day mortality in patients with acute pulmonary embolism (PE). We constructed a simplified version of the PESI.

Link:Prospective validation of the Pulmonary Embolism Severity Index, Donzé J, et al.

Practice guidelines recommend outpatient care for selected patients with non-massive pulmonary embolism (PE), but fail to specify how these low-risk patients should be identified.


Link:Outpatient versus inpatient treatment in patients with pulmonary embolism: a meta-analysis, Zondag W, et al.

This article studies the safety of outpatient treatment in low risk patients with acute pulmonary embolism compared with inpatient treatment, the current clinical standard.

Link:Inpatient resource use and cost burden of deep vein thrombosis and pulmonary embolism in the United States, LaMori JC, et al.

Venous thromboembolism (VTE), which comprises deep vein thrombosis (DVT) and pulmonary embolism (PE), is associated with significant morbidity and mortality. VTE frequently leads to hospitalization and represents a considerable economic burden to the US health care system. However, little information exists on the duration of hospitalization and associated charges among patients with an admitting or primary diagnosis of DVT or PE. This study assessed the charges associated with hospitalization length of stay in patients with DVT or PE discharged from US hospitals in 2011.

Link:The long-term clinical course of acute deep venous thrombosis, Prandoni P, et al.

In patients who have symptomatic deep venous thrombosis, the long-term risk for recurrent venous thromboembolism and the incidence and severity of post-thrombotic sequelae have not been well documented.


PDF:Predictors of Hospital Length of Stay among Patients with Low-risk Pulmonary Embolism, Wang L. et al.

Pulmonary embolism (PE) is responsible for 300,000 US deaths each year. Initial PE-related hospitalization costs were estimated at $13,300-$31,000 annually.

Link:The Value of sPESI for Risk Stratification in Patients with Pulmonary Embolism, Wells P, et al.

Various risk stratification methods exist for patients with pulmonary embolism (PE). Use the simplified Pulmonary Embolism Severity Index (sPESI) as a risk stratification method to understand the PE population within the Veterans Health Administration (VHA).

PDF:Benefit of early discharge among patients with low-risk pulmonary embolism, Wang L. et al.

Clinical guidelines recommend early discharge of patients with low-risk pulmonary embolism (LRPE). This study measured the overall impact of early discharge of LRPE patients on clinical outcomes and costs in the Veterans Health Administration population.

Link:Direct medical costs of venous thromboembolism and subsequent hospital readmission rates: an administrative claims analysis from 30 managed care organizations, Spyropoulos AC, et al.

Venous thromboembolism (VTE) is a common medical condition manifested as deep vein thrombosis (DVT) or pulmonary embolism (PE). Few data exist on the total economic burden of DVT and PE.

Link:Thrombolysis for pulmonary embolism and risk of all-cause mortality, major bleeding, and intracranial hemorrhage: a meta-analysis, Chatterjee S, et al.

Thrombolytic therapy may be beneficial in the treatment of some patients with pulmonary embolism. To date, no analysis has had adequate statistical power to determine whether thrombolytic therapy is associated with improved survival, compared with conventional anticoagulation.

Link:Outpatient treatment of symptomatic pulmonary embolism: A systematic review and meta-analysis, Piran S, et al.

Patients with acute deep vein thrombus (DVT) can safely be treated as outpatients. However the role of outpatient treatment in patients diagnosed with a pulmonary embolism (PE) is controversial. The authors sought to determine the safety of outpatient management of patients with acute symptomatic PE.

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Our vision is to improve the lives of the millions of people with cardiovascular disease and diabetes, and to work tirelessly to eliminate these diseases. Every year 19 million people around the world die from cardiovascular and metabolic diseases. This tremendous global burden compels us to develop new therapies that will change the face of these diseases and, ultimately, eliminate them. We focus on finding and developing truly transformational therapies that target underlying disease pathways, important pathways, and novel mechanisms of action. We have a very successful track record demonstrated by the development and recent successful launches of our products for the treatment of patients suffering from thrombosis and type 2 diabetes. And we continue to seek and develop the next generation of transformational cardiovascular and metabolic therapies.

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We want to drive down the rates of cardiovascular and metabolic diseases with our science, innovation, and solutions. We are already transforming the treatment of type 2 diabetes and thrombosis with our products. And while these important products continue to change the way doctors are treating diabetes and thrombosis, we are also focused on finding the next wave of transformational treatments for cardiovascular and metabolic diseases that will prevent, intercept, and cure devastating diseases.